Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells
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چکیده
منابع مشابه
Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells
Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Accumulation of advanced glycation end products (AGEs) is a major pathologic event in DR. While diabetes leads to a decrease in the Kir4.1 channels, it remains unknown whether AGEs-linked to the basement membrane (BM)...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0193280